Ireland went down by 79 runs in the 3rd and final ODI, making 214 all out in reply to the Bangladesh score of 293 for 7.
Niall O'Brien (70) led a valiant rearguard, hitting 4 fours and a six in his 74 ball stay at the wicket. However, the Irish didn't help their cause by being involved in four run outs, including opener William Porterfield (18), and skipper Trent Johnston from the first ball he faced.
Reinhardt Strydom (37) batted well, but after being handily placed at 84 for 2, and 126 for 3, the Irish again lost wickets in clusters and were never able to build any sort of momentum.
Spinners Abdur Razzak (2-50), and Shakib Al Hasan (2-46) were the most successful of the Bangladesh attack.
Earlier, Bangladesh had got off to a flying start, having won the toss and elected to bat, with openers Shariar Nafees and Tamim Iqbal put on 100 in exactly 17 overs.
Nafees reached his half century from 49 deliveries, striking 9 fours, while Iqbal reached his 50 from 61 balls, having hit 8 fours.
There were ominious signs that it wasn't going to be Ireland's day, as Dave Langford-Smith bowled 4 wides in the first over of the day, more than they conceded in 50 overs of play on Thursday.
Kevin O'Brien fared no better, conceding 4 boundaries to Nafees in his opening two overs, which forced skipper Johnston into a double bowling change.
Andre Botha did his best to stem the tide, and should have been rewarded with the opening wicket when Iqbal on 30 skied the ball, but the bowler himself spilled the chance. The total at the stage was 69.
A double wicket maiden from Alex Cusack lifted flagging Irish spirirts after a nightmare start. Cusack removed Shariar Nafees (54), caught by Strydom at mid-on with the score on 109. Just two balls later he then bowled the dangerous Aftab Ahmed for 0, and things were looking a bit brighter for the beleagured Irish.
Two wickets from Kevin O'Brien and one from Dave Langford-Smith brought them back into contention at 178 for 5, but 129 from Tamim Iqbal helped Bangaldesh steady the innings and post 293 for 7 - their second highest ever score in ODI's.
Iqbal struck 15 fours and a six in his 137 ball stay at the crease, and his score of 129 was the second highest indivisual score in a ODI by a Bangladesh player.
He shared a vital partnership of 82 run in just 10.2 overs with Mahmadullah (49*), to effectively end the game as a contest.
Dave Langford-Smith (3-53) again took 3 wickets, while Alex Cusack (2-30), and Kevin O'Brien (2-58) each picked up two, but it was a far from impressive bowling display by the Irish.
Ireland now return home to begin their domestic campaign with 8 games in the Friends Provident Trophy, starting with a home fixture with Notts on April 27, which will be the televised game on Sky Sports.

